Cellular response to nitrogen starvation

Across TCGA patient cohorts, RNA activity of the Cellular response to nitrogen starvation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB42, FAM155A, and MTHFD1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to nitrogen starvation activity versus ZBTB42 in LUAD (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ZBTB42 →	-0.569	-0.153	<.001	.001	3	3
LUAD	FAM155A →	+0.534	+0.190	<.001	<.001	3	3
PDAC	MTHFD1 →	-0.278	-0.174	.003	.001	3	3
PDAC	TTLL10 →	-0.196	-0.164	.004	<.001	3	3
PDAC	RPL21P107 →	+0.210	+0.155	.006	.007	3	3
PDAC	CAD →	-0.293	-0.165	.009	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006995 vs ZBTB42 — LUAD

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