Cellular response to nitrogen starvation

Across TCGA cell cohorts, RNA activity of the Cellular response to nitrogen starvation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ESPL1, DRAM1, and MFSD14C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to nitrogen starvation activity versus ESPL1 in SOFT_TISSUE (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ESPL1 →	+0.811	+0.345	.004	.004	3	3
BLOOD_Lymphoma	DRAM1 →	-3.132	-1.891	.001	<.001	3	3
SOFT_TISSUE	MFSD14C →	+1.067	+0.345	.002	.004	2	4
SOFT_TISSUE	PDXP →	+1.422	+0.345	.005	.004	3	3
SOFT_TISSUE	E2F2 →	+2.329	+0.345	<.001	.004	3	3
PANCREAS	MRPL4 →	+1.085	+1.972	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006995 vs ESPL1 — SOFT_TISSUE

Explore this scatter interactively →