Response to sterol depletion

Across TCGA patient cohorts, RNA activity of the Response to sterol depletion pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAPRE3_S176, NOLC1, and NOLC1_S538, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to sterol depletion activity versus MAPRE3_S176 in UCEC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAPRE3_S176 →	+0.481	+0.063	<.001	<.001	3	6
OV	NOLC1 →	-0.558	-0.063	.001	<.001	3	6
OV	NOLC1_S538 →	-0.712	-0.046	.005	<.001	3	6
GBM	LCP2 →	+0.400	+0.057	<.001	<.001	3	6
LSCC	RNASE6 →	+0.437	+0.051	<.001	<.001	3	5
OV	RRP7A →	-0.399	-0.041	.002	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006991 vs MAPRE3_S176 — UCEC

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