Response to sterol depletion

Across TCGA patient cohorts, RNA activity of the Response to sterol depletion pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CASP5, BATF2, and LYN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to sterol depletion activity versus CASP5 in HNSC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CASP5 →	+0.623	+0.113	<.001	<.001	3	4
BRCA	BATF2 →	+1.137	+0.664	.005	.002	3	4
LSCC	LYN →	+0.642	+0.500	<.001	<.001	3	3
GBM	NORAD →	-0.329	-0.193	.008	.006	3	3
LSCC	IFIT3 →	+1.238	+0.495	<.001	<.001	3	3
LSCC	EXTL2 →	-0.477	-0.457	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006991 vs CASP5 — HNSC

Explore this scatter interactively →