Response to sterol depletion

Across TCGA cell cohorts, RNA activity of the Response to sterol depletion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACER3, NEXN, and IFNGR2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACER3 grouped by Response to sterol depletion-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ACER3 →	+0.990	+1.203	.001	.002	3	4
LUNG_NSCLC_LUSC	NEXN →	-3.643	-1.265	<.001	.005	3	4
STOMACH	IFNGR2 →	-1.296	-1.231	.005	.004	3	4
OVARY	TMEM45A →	-1.599	-1.124	<.001	<.001	3	4
URINARY_TRACT	TBX3 →	+3.497	+1.791	.005	.004	3	4
URINARY_TRACT	MYO6 →	+2.525	+2.219	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACER3 by Response to sterol depletion activity — BLOOD_Leukemia

Explore this box plot interactively →