Response to sterol depletion

Across TCGA cell cohorts, RNA activity of the Response to sterol depletion pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERLIN2, RASL10B, and SLC66A1, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to sterol depletion activity versus ERLIN2 in BREAST (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ERLIN2 →	+1.318	+0.977	<.001	<.001	3	11
LUNG_SCLC	RASL10B →	-2.455	-1.330	<.001	<.001	3	5
BLOOD_Leukemia	SLC66A1 →	+1.074	+1.137	<.001	<.001	3	5
BLOOD_Leukemia	ZGPAT →	-0.613	-0.910	<.001	.002	3	5
BLOOD_Myeloma	RNF170 →	+2.218	+1.294	.006	.009	3	5
BREAST	PLPBP →	+1.642	+1.612	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006991 vs ERLIN2 — BREAST

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