ER-nucleus signaling pathway

Across TCGA patient cohorts, RNA activity of the ER-nucleus signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN4, LTBP2, and SEPTIN4_S432, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ER-nucleus signaling pathway activity versus SEPTIN4 in PDAC (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SEPTIN4 →	+0.501	+0.038	<.001	.001	3	7
CCRCC	LTBP2 →	+0.745	+0.032	.004	.003	3	7
PDAC	SEPTIN4_S432 →	+0.593	+0.046	<.001	<.001	3	6
BRCA	SH3D19 →	+0.424	+0.033	<.001	.001	3	6
LUAD	RPL31_S98 →	-0.789	-0.048	.005	<.001	3	6
GBM	WDR4_S391 →	-0.541	-0.038	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006984 vs SEPTIN4 — PDAC

Explore this scatter interactively →