ER-nucleus signaling pathway

Across TCGA cell cohorts, RNA activity of the ER-nucleus signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TERF2, HTR3A, and ITGB7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TERF2 grouped by ER-nucleus signaling pathway-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TERF2 →	-0.608	-1.283	<.001	.007	3	4
CNS	HTR3A →	+0.020	+0.814	.005	.001	3	4
SOFT_TISSUE	ITGB7 →	-0.244	-1.154	.001	.002	3	4
SOFT_TISSUE	C16orf95 →	-0.914	-1.437	.003	.003	3	4
BONE	GALNT14 →	+3.136	+1.677	<.001	.001	3	3
BONE	TIGD4 →	+0.229	+1.176	.004	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TERF2 by ER-nucleus signaling pathway activity — LIVER

Explore this box plot interactively →