ER overload response

Across TCGA patient cohorts, RNA activity of the ER overload response pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NOLC1_S538, FBLN1, and DDX21_S121, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ER overload response activity versus NOLC1_S538 in PDAC (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	NOLC1_S538 →	-0.504	-0.051	.001	<.001	3	5
BRCA	FBLN1 →	+0.382	+0.031	.005	.007	2	6
LUAD	DDX21_S121 →	-0.469	-0.038	.007	.002	2	6
HNSC	MAP1B_S1779 →	+0.572	+0.060	.002	<.001	3	4
HNSC	ANK2_S890 →	+0.592	+0.074	.005	.003	3	4
UCEC	LRPPRC →	-0.261	-0.073	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006983 vs NOLC1_S538 — PDAC

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