ER overload response

Across TCGA patient cohorts, RNA activity of the ER overload response pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSD11B1, MIR4705, and TCEAL4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ER overload response activity versus HSD11B1 in GBM (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HSD11B1 →	-1.070	-0.152	<.001	.002	3	3
GBM	MIR4705 →	+1.208	+0.124	<.001	<.001	3	3
UCEC	TCEAL4 →	-0.420	-0.209	.002	.007	3	3
UCEC	TRANK1 →	-0.472	-0.245	.009	.009	3	3
BRCA	MADD →	-0.320	-0.355	.009	.002	3	3
PDAC	TEX10 →	-0.257	-0.674	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006983 vs HSD11B1 — GBM

Explore this scatter interactively →