ER overload response

Across TCGA cell cohorts, RNA activity of the ER overload response pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZMAT3, RPS27L, and CDKN1A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZMAT3 grouped by ER overload response-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZMAT3 →	-1.296	-1.050	<.001	<.001	3	8
STOMACH	RPS27L →	-1.114	-1.105	.003	.005	3	7
SKIN	CDKN1A →	-2.605	-1.080	<.001	<.001	3	7
URINARY_TRACT	DDB2 →	-1.706	-1.838	.001	<.001	3	6
STOMACH	MDM2 →	-1.748	-2.189	.006	<.001	3	6
SOFT_TISSUE	EDA2R →	-2.431	-1.507	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZMAT3 by ER overload response activity — SKIN

Explore this box plot interactively →