ER overload response

Across TCGA cell cohorts, RNA activity of the ER overload response pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPSA, SCLY, and GNL3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ER overload response activity versus RPSA in PANCREAS (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RPSA →	-1.120	-1.185	.004	.002	3	6
LARGE_INTESTINE	SCLY →	-0.516	-0.946	.001	<.001	3	4
OVARY	GNL3 →	-1.058	-1.110	<.001	<.001	3	4
LARGE_INTESTINE	ABCE1 →	-0.879	-1.297	.003	<.001	2	5
OVARY	DUS2 →	-0.564	-1.040	.001	<.001	3	4
LARGE_INTESTINE	PFAS →	-0.568	-0.796	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006983 vs RPSA — PANCREAS

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