Across TCGA patient cohorts, RNA activity of the "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest" pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.
The most reproducible pathway-associated proteins across cancer lineages are RRM2_S20, BUB1B_S543, and NASP_S244, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.
Each partner is linked to its corresponding Q-omics profile.