Hyperosmotic response

Across TCGA patient cohorts, RNA activity of the Hyperosmotic response pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLCO4A1, IL1A, and MTHFD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hyperosmotic response activity versus SLCO4A1 in BRCA (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLCO4A1 →	+0.479	+0.123	.004	.005	3	5
BRCA	IL1A →	+0.416	+0.128	.002	.003	3	4
BRCA	MTHFD2 →	+0.585	+0.204	<.001	.001	3	4
OV	COG3 →	-0.359	-0.128	.001	.001	3	4
OV	RGL4 →	+0.209	+0.168	.003	.001	3	4
BRCA	COTL1 →	+0.529	+0.147	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006972 vs SLCO4A1 — BRCA

Explore this scatter interactively →