Hyperosmotic response

Across TCGA cell cohorts, RNA activity of the Hyperosmotic response pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WNK1, XRCC6, and COPS7A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WNK1 grouped by Hyperosmotic response-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	WNK1 →	-0.492	-0.369	<.001	.004	3	6
LUNG_NSCLC_LUSC	XRCC6 →	-0.376	-0.410	.001	.006	2	6
BLOOD_Lymphoma	COPS7A →	-0.324	-0.326	<.001	.007	3	4
SOFT_TISSUE	TSPAN5 →	-0.240	-0.223	.008	.009	3	4
OVARY	SYT12 →	+0.186	+0.208	.001	<.001	3	4
OVARY	MTOR →	-0.230	-0.205	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WNK1 by Hyperosmotic response activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →