Hyperosmotic response

Across TCGA cell cohorts, RNA activity of the Hyperosmotic response pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MPP1, BAG1, and ETS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MPP1 grouped by Hyperosmotic response-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MPP1 →	-1.799	-0.270	.001	<.001	3	5
BLOOD_Myeloma	BAG1 →	+1.206	+0.253	.001	.005	3	4
URINARY_TRACT	ETS1 →	-2.109	-0.296	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	EHHADH →	+0.938	+0.309	.002	.001	3	4
BREAST	TFF1 →	+5.047	+0.211	.002	.004	3	4
SKIN	ARPC1B →	-0.711	-0.657	.005	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MPP1 by Hyperosmotic response activity — BREAST

Explore this box plot interactively →