Hyperosmotic response

Across TCGA cell cohorts, RNA activity of the Hyperosmotic response pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IPO4, HOXD13, and LTBP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IPO4 grouped by Hyperosmotic response-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	IPO4 →	+0.333	+0.146	.003	.007	3	6
SKIN	HOXD13 →	+0.116	+0.075	.001	.001	3	5
CNS	LTBP1 →	+0.154	+0.077	<.001	.002	3	5
BLOOD_Leukemia	SRPK1 →	-0.239	-0.084	.005	.007	3	4
URINARY_TRACT	TELO2 →	-0.198	-0.139	.002	.002	3	4
LUNG_SCLC	KCNA5 →	-0.250	-0.156	<.001	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IPO4 by Hyperosmotic response activity — BONE

Explore this box plot interactively →