Hypotonic response

Across TCGA patient cohorts, RNA activity of the Hypotonic response pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRP9, GEMIN5, and VCL, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hypotonic response activity versus RRP9 in GBM (Pearson r = -0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RRP9 →	-0.281	-0.063	<.001	<.001	3	8
CCRCC	GEMIN5 →	-0.240	-0.109	<.001	<.001	3	8
COAD	VCL →	+0.493	+0.064	<.001	<.001	3	8
GBM	FEN1 →	-0.492	-0.086	<.001	<.001	3	8
COAD	HNMT →	+0.368	+0.068	<.001	<.001	3	8
GBM	URB2 →	-0.227	-0.075	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006971 vs RRP9 — GBM

Explore this scatter interactively →