Hypotonic response

Across TCGA patient cohorts, RNA activity of the Hypotonic response pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LPP, MYLK, and CSRP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hypotonic response activity versus LPP in UCEC (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LPP →	+0.637	+0.224	<.001	<.001	3	8
UCEC	MYLK →	+0.774	+0.254	.001	<.001	3	8
UCEC	CSRP1 →	+0.861	+0.313	<.001	<.001	3	7
PDAC	MYL6 →	+0.501	+0.229	<.001	<.001	3	7
UCEC	TGFB1I1 →	+0.761	+0.300	.001	<.001	3	6
UCEC	TPM1 →	+0.649	+0.234	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006971 vs LPP — UCEC

Explore this scatter interactively →