Hypotonic response

Across TCGA cell cohorts, RNA activity of the Hypotonic response pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RGS2, LNX1, and ABHD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RGS2 grouped by Hypotonic response-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RGS2 →	-1.148	-1.581	.002	<.001	3	4
BREAST	LNX1 →	+1.165	+1.189	.001	<.001	3	4
STOMACH	ABHD2 →	+2.328	+1.045	.001	.002	3	4
STOMACH	KLF13 →	+1.488	+1.330	<.001	<.001	3	4
STOMACH	CANT1 →	+1.214	+1.161	.009	<.001	3	4
LUNG_NSCLC_LUSC	ZNF442 →	-0.674	-1.182	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RGS2 by Hypotonic response activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →