Hypotonic response

Across TCGA cell cohorts, RNA activity of the Hypotonic response pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RIPK3, CDCP1, and PLEK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hypotonic response activity versus RIPK3 in URINARY_TRACT (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RIPK3 →	+2.444	+0.269	.001	.008	3	4
SKIN	CDCP1 →	+1.585	+0.811	.002	.001	2	5
LUNG_NSCLC_LUAD	PLEK2 →	+1.181	+0.458	.004	.009	3	4
LUNG_NSCLC_LUAD	TMEM51 →	+1.017	+0.826	.001	.001	3	4
PANCREAS	ITGA2 →	+3.269	+1.542	<.001	.001	3	3
PANCREAS	P2RY1 →	+0.928	+0.843	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006971 vs RIPK3 — URINARY_TRACT

Explore this scatter interactively →