Cellular defense response

Across TCGA patient cohorts, RNA activity of the Cellular defense response pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEK, RHOH, and SIRPB1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular defense response activity versus PLEK in OV (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PLEK →	+1.214	+0.247	<.001	<.001	3	10
LSCC	RHOH →	+0.777	+0.341	<.001	<.001	3	10
CCRCC	SIRPB1 →	+0.707	+0.357	<.001	<.001	3	10
HNSC	CYTIP →	+1.317	+0.388	<.001	<.001	3	10
HNSC	STX11 →	+0.648	+0.360	.002	<.001	3	10
GBM	BCL2A1 →	+1.336	+0.300	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006968 vs PLEK — OV

Explore this scatter interactively →