Cellular defense response

Across TCGA cell cohorts, RNA activity of the Cellular defense response pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B2M, RPS9, and ANXA1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular defense response activity versus B2M in BREAST (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	B2M →	+1.782	+0.481	<.001	<.001	3	8
OVARY	RPS9 →	-0.687	-0.299	.004	<.001	3	7
BREAST	ANXA1 →	+3.403	+0.473	<.001	.005	3	7
BREAST	PSMB8 →	+2.170	+0.407	<.001	.001	3	7
STOMACH	RPL13A →	-1.140	-0.710	<.001	.009	3	6
BONE	IRF1 →	+1.795	+0.543	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006968 vs B2M — BREAST

Explore this scatter interactively →