Humoral immune response

Across TCGA cell cohorts, RNA activity of the Humoral immune response pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM205, NUDT8, and SSH3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM205 grouped by Humoral immune response-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TMEM205 →	-1.402	-0.913	.007	.009	3	4
LUNG_NSCLC_LUAD	NUDT8 →	-1.152	-0.793	.001	.004	3	3
LUNG_NSCLC_LUAD	SSH3 →	-0.807	-0.577	.002	.008	3	3
LUNG_NSCLC_LUAD	PTPN18 →	-0.421	-0.730	.007	.003	3	3
KIDNEY	TTC12 →	-0.886	-0.928	.007	.008	3	3
BREAST	PTK6 →	-1.453	-0.326	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM205 by Humoral immune response activity — BLOOD_Leukemia

Explore this box plot interactively →