Humoral immune response

Across TCGA cell cohorts, RNA activity of the Humoral immune response pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPO, EIF4B, and SBNO1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Humoral immune response activity versus TSPO in BLOOD_Leukemia (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TSPO →	+2.334	+0.365	.005	.003	2	8
BLOOD_Leukemia	EIF4B →	-0.685	-0.255	.002	.001	3	5
BONE	SBNO1 →	-0.914	-0.258	<.001	.007	3	5
BLOOD_Leukemia	C9orf64 →	+1.846	+0.349	<.001	<.001	3	5
BLOOD_Leukemia	FGD6 →	-0.727	-0.327	.005	.003	2	6
UPPER_AERODIGESTIVE_TRACT	S100A6 →	+1.020	+0.200	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006959 vs TSPO — BLOOD_Leukemia

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