"Complement activation, classical pathway"

Across TCGA patient cohorts, RNA activity of the "Complement activation, classical pathway" pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WAS, WIPF1, and DOCK2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Complement activation, classical pathway" activity versus WAS in BRCA (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	WAS →	+0.485	+0.122	<.001	<.001	3	10
HNSC	WIPF1 →	+0.430	+0.116	<.001	<.001	3	10
LSCC	DOCK2 →	+0.578	+0.104	<.001	<.001	3	10
GBM	HCLS1 →	+0.638	+0.095	<.001	<.001	3	10
HNSC	IL16 →	+0.622	+0.107	<.001	.001	3	10
LSCC	ANKRD44 →	+0.464	+0.109	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006958 vs WAS — BRCA

Explore this scatter interactively →