"Complement activation, classical pathway"

Across TCGA cell cohorts, RNA activity of the "Complement activation, classical pathway" pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRMT3, TRIT1, and CCDC97, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRMT3 grouped by "Complement activation, classical pathway"-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PRMT3 →	+0.521	+1.009	.007	.006	3	4
PANCREAS	TRIT1 →	+0.575	+0.979	<.001	.004	3	4
URINARY_TRACT	CCDC97 →	+0.850	+1.783	.009	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	CSNK1G1 →	+0.688	+0.338	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	LLGL2 →	+1.286	+0.866	.001	.004	3	4
LIVER	SSX2IP →	+1.460	+1.321	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRMT3 by "Complement activation, classical pathway" activity — SKIN

Explore this box plot interactively →