"Complement activation, classical pathway"

Across TCGA cell cohorts, RNA activity of the "Complement activation, classical pathway" pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF37A, LY6H, and PEX7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF37A grouped by "Complement activation, classical pathway"-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ZNF37A →	+0.177	+1.280	.002	.004	3	5
BLOOD_Leukemia	LY6H →	-0.146	-1.075	.008	.003	3	5
URINARY_TRACT	PEX7 →	-0.103	-1.680	.004	<.001	3	4
OESOPHAGUS	MRPS33 →	-0.436	-2.233	.006	.001	3	4
BLOOD_Leukemia	INPPL1 →	-0.280	-1.176	.001	.002	3	4
BLOOD_Leukemia	PER3 →	+0.384	+1.247	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF37A by "Complement activation, classical pathway" activity — OESOPHAGUS

Explore this box plot interactively →