"Complement activation, classical pathway"

Across TCGA cell cohorts, RNA activity of the "Complement activation, classical pathway" pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NLRP2, CD37, and ALDH9A1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NLRP2 grouped by "Complement activation, classical pathway"-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NLRP2 →	+0.343	+1.711	.006	.002	2	2
LUNG_SCLC	CD37 →	+0.265	+1.841	.003	.002	2	2
LUNG_SCLC	ALDH9A1 →	+0.300	+1.841	<.001	.002	2	2
LUNG_SCLC	TRIP12 →	+0.655	+1.841	.009	.002	2	2
BREAST	PSMB5 →	+1.350	+2.266	.002	.008	3	1
BREAST	HSPA8 →	+0.675	+2.266	.007	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NLRP2 by "Complement activation, classical pathway" activity — LUNG_SCLC

Explore this box plot interactively →