"Complement activation, classical pathway"

Across TCGA cell cohorts, RNA activity of the "Complement activation, classical pathway" pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF514, C5orf63, and SEMA4G, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Complement activation, classical pathway" activity versus ZNF514 in BLOOD_Lymphoma (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZNF514 →	+1.359	+1.522	<.001	<.001	3	2
BLOOD_Lymphoma	C5orf63 →	+2.452	+1.677	.001	<.001	3	2
BLOOD_Lymphoma	SEMA4G →	+0.709	+1.862	.001	<.001	3	1
BLOOD_Lymphoma	DBN1 →	+4.242	+1.879	<.001	<.001	3	1
BLOOD_Lymphoma	GALNT12 →	+1.717	+1.723	.004	<.001	3	1
BLOOD_Lymphoma	NCAPD3 →	-0.838	-1.522	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006958 vs ZNF514 — BLOOD_Lymphoma

Explore this scatter interactively →