"Complement activation, alternative pathway"

Across TCGA patient cohorts, RNA activity of the "Complement activation, alternative pathway" pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OGN, STAB1, and BGN, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Complement activation, alternative pathway" activity versus OGN in CCRCC (Pearson r = -0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	OGN →	+0.874	+0.122	<.001	<.001	3	10
GBM	STAB1 →	+0.449	+0.119	<.001	<.001	3	9
GBM	BGN →	+0.950	+0.152	<.001	<.001	3	9
GBM	PRELP →	+0.923	+0.134	<.001	<.001	3	9
GBM	GGT5 →	+0.586	+0.114	.001	.002	3	9
CCRCC	SORBS1 →	+0.442	+0.104	.008	.001	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006957 vs OGN — CCRCC

Explore this scatter interactively →