"Complement activation, alternative pathway"

Across TCGA patient cohorts, RNA activity of the "Complement activation, alternative pathway" pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FN1, MEDAG, and SERPINE1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Complement activation, alternative pathway" activity versus FN1 in OV (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FN1 →	+2.627	+0.312	<.001	<.001	3	9
COAD	MEDAG →	+1.105	+0.207	<.001	<.001	3	8
OV	SERPINE1 →	+1.226	+0.183	<.001	<.001	3	8
COAD	DSE →	+0.528	+0.160	<.001	<.001	3	8
OV	GFPT2 →	+1.068	+0.219	<.001	.001	3	8
OV	ADAMTS12 →	+1.281	+0.261	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006957 vs FN1 — OV

Explore this scatter interactively →