"Complement activation, alternative pathway"

Across TCGA cell cohorts, RNA activity of the "Complement activation, alternative pathway" pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VSIG10L, TGFBR1, and CCDC88B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VSIG10L grouped by "Complement activation, alternative pathway"-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	VSIG10L →	-1.803	-0.452	.001	.001	3	4
SOFT_TISSUE	TGFBR1 →	+1.299	+0.918	.007	.005	3	4
LIVER	CCDC88B →	-1.520	-0.442	.001	.002	3	3
LIVER	HINT1 →	+0.580	+0.434	.006	.003	2	4
SKIN	RCAN1 →	-1.445	-0.811	.009	.005	3	3
OVARY	CHCHD4 →	-0.709	-0.477	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VSIG10L by "Complement activation, alternative pathway" activity — STOMACH

Explore this box plot interactively →