Complement activation

Across TCGA patient cohorts, RNA activity of the Complement activation pathway is significantly associated with the RNA expression of multiple genes, with the BLCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1QB, C1QA, and IGKV3D-20, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Complement activation activity versus C1QB in BLCA (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	C1QB →	+2.695	+0.129	<.001	<.001	3	33
BLCA	C1QA →	+2.676	+0.130	<.001	<.001	3	33
THCA	IGKV3D-20 →	+3.513	+0.172	<.001	<.001	3	33
THCA	IGKV3D-11 →	+2.614	+0.166	<.001	<.001	3	33
THCA	IGLV4-69 →	+4.199	+0.167	<.001	<.001	3	33
THCA	IGLV1-47 →	+4.755	+0.169	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006956 vs C1QB — BLCA

Explore this scatter interactively →