Complement activation

Across TCGA cell cohorts, RNA activity of the Complement activation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTREX, GDF15, and ATXN7L1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MTREX grouped by Complement activation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MTREX →	+1.033	+0.350	<.001	<.001	3	4
SKIN	GDF15 →	-3.471	-0.718	<.001	.008	3	4
SKIN	ATXN7L1 →	-0.567	-0.810	.003	.001	3	4
LUNG_SCLC	BTAF1 →	+1.243	+0.396	.001	.002	3	4
LUNG_SCLC	AP3M1 →	+0.863	+0.361	<.001	<.001	3	4
PANCREAS	POU2F1 →	+0.380	+0.277	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MTREX by Complement activation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →