Complement activation

Across TCGA cell cohorts, RNA activity of the Complement activation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP7B, ADCY3, and PSMB10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Complement activation activity versus ATP7B in BLOOD_Leukemia (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ATP7B →	+2.154	+0.846	<.001	<.001	3	4
BLOOD_Lymphoma	ADCY3 →	-1.093	-0.656	.001	.002	2	5
BLOOD_Leukemia	PSMB10 →	-0.843	-0.783	.006	.001	3	3
LUNG_SCLC	NGRN →	+0.824	+0.993	.007	.001	3	3
OESOPHAGUS	PIP5K1C →	-0.625	-0.599	.002	.003	3	3
OESOPHAGUS	MYBBP1A →	-0.855	-0.608	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006956 vs ATP7B — BLOOD_Leukemia

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