Regulation of striated muscle contraction

Across TCGA cell cohorts, RNA activity of the Regulation of striated muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRSS22, PLSCR1, and ADGRF1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of striated muscle contraction activity versus PRSS22 in STOMACH (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PRSS22 →	+3.756	+0.435	.002	.005	3	7
LARGE_INTESTINE	PLSCR1 →	+1.154	+0.196	.001	.006	3	7
OVARY	ADGRF1 →	+1.958	+0.226	.003	.004	3	7
URINARY_TRACT	KCNK1 →	+2.506	+0.261	.002	.009	3	6
LUNG_NSCLC_LUAD	CDA →	+3.204	+0.266	<.001	.001	3	6
URINARY_TRACT	LAMA3 →	+4.066	+0.322	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006942 vs PRSS22 — STOMACH

Explore this scatter interactively →