Regulation of smooth muscle contraction

Across TCGA cell cohorts, RNA activity of the Regulation of smooth muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA2, ADRA2C, and WDR48, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of smooth muscle contraction activity versus ITGA2 in LUNG_NSCLC_LUSC (Pearson r = 0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ITGA2 →	+3.622	+0.278	.003	<.001	3	5
LIVER	ADRA2C →	-2.387	-0.337	<.001	<.001	3	5
PANCREAS	WDR48 →	-0.922	-0.303	.007	.006	3	5
LIVER	TGFBI →	+5.664	+0.303	.005	.002	3	4
SKIN	AIF1L →	-2.651	-0.364	.001	<.001	3	4
LUNG_NSCLC_LUSC	PLEK2 →	+3.240	+0.185	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006940 vs ITGA2 — LUNG_NSCLC_LUSC

Explore this scatter interactively →