Smooth muscle contraction

Across TCGA cell cohorts, RNA activity of the Smooth muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A39, SCP2, and GBP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Smooth muscle contraction activity versus SLC25A39 in BREAST (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SLC25A39 →	-0.712	-0.914	<.001	<.001	3	5
CNS	SCP2 →	+0.655	+0.871	.006	.007	2	5
CNS	GBP3 →	+1.411	+0.885	.003	<.001	3	4
BREAST	ZC3H8 →	-0.532	-0.935	.007	.002	3	4
CNS	METTL2A →	-0.341	-0.980	.006	<.001	3	4
BONE	SLC26A6 →	+1.186	+1.608	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006939 vs SLC25A39 — BREAST

Explore this scatter interactively →