"Substrate-dependent cell migration, cell extension"

Across TCGA patient cohorts, RNA activity of the "Substrate-dependent cell migration, cell extension" pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHTN1, ANKRD36, and PIK3C2A, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Substrate-dependent cell migration, cell extension" activity versus SHTN1 in UVM (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	SHTN1 →	+1.217	+0.038	<.001	<.001	3	29
TGCT	ANKRD36 →	+0.802	+0.065	<.001	<.001	3	27
THYM	PIK3C2A →	+1.262	+0.072	<.001	<.001	3	26
THYM	SMG1 →	+0.865	+0.059	<.001	<.001	3	26
UCS	ANKRD36B →	+0.626	+0.102	<.001	<.001	3	26
THYM	FNDC3B →	+1.340	+0.081	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006930 vs SHTN1 — UVM

Explore this scatter interactively →