"Substrate-dependent cell migration, cell extension"

Across TCGA patient cohorts, RNA activity of the "Substrate-dependent cell migration, cell extension" pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM159, CTTN, and MVP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Substrate-dependent cell migration, cell extension" activity versus TMEM159 in LUAD (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TMEM159 →	+0.804	+0.345	<.001	<.001	3	5
HNSC	CTTN →	+1.062	+0.437	<.001	.001	3	4
GBM	MVP →	+1.011	+0.455	<.001	<.001	3	4
GBM	POLD4 →	+0.631	+0.423	<.001	<.001	3	4
PDAC	ARHGAP27 →	+0.422	+0.416	<.001	<.001	3	4
UCEC	ANG →	+0.728	+0.191	.007	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006930 vs TMEM159 — LUAD

Explore this scatter interactively →