"Substrate-dependent cell migration, cell extension"

Across TCGA cell cohorts, RNA activity of the "Substrate-dependent cell migration, cell extension" pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JPH1, SYTL2, and RIOK1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, JPH1 grouped by "Substrate-dependent cell migration, cell extension"-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	JPH1 →	+2.732	+1.573	.003	<.001	3	4
BONE	SYTL2 →	-2.794	-1.614	.004	<.001	3	4
BLOOD_Lymphoma	RIOK1 →	+1.487	+1.707	<.001	<.001	3	4
STOMACH	CDKN1A →	-3.355	-1.708	.001	<.001	3	3
SOFT_TISSUE	KLF5 →	+2.761	+1.125	<.001	.007	3	3
BONE	MICU1 →	-1.069	-2.009	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JPH1 by "Substrate-dependent cell migration, cell extension" activity — BONE

Explore this box plot interactively →