"Substrate-dependent cell migration, cell extension"

Across TCGA cell cohorts, RNA activity of the "Substrate-dependent cell migration, cell extension" pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD2AP, NRP1, and PIP4K2A, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Substrate-dependent cell migration, cell extension" activity versus CD2AP in PANCREAS (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CD2AP →	+0.983	+0.154	<.001	.001	3	13
SOFT_TISSUE	NRP1 →	+3.031	+0.179	<.001	<.001	3	12
PANCREAS	PIP4K2A →	+1.120	+0.151	.001	.003	3	8
LUNG_NSCLC_LUSC	TSPAN33 →	-2.694	-0.226	.001	.002	3	7
LUNG_NSCLC_LUAD	DCBLD2 →	+2.056	+0.141	<.001	.004	3	7
KIDNEY	NTN1 →	-1.414	-0.236	.004	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006930 vs CD2AP — PANCREAS

Explore this scatter interactively →