"Substrate-dependent cell migration, cell extension"

Across TCGA cell cohorts, RNA activity of the "Substrate-dependent cell migration, cell extension" pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF594, COPA, and PIP4K2A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Substrate-dependent cell migration, cell extension" activity versus ZNF594 in SOFT_TISSUE (Pearson r = -0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ZNF594 →	-0.923	-1.365	.004	.001	3	6
URINARY_TRACT	COPA →	+0.836	+1.729	.003	<.001	3	5
SOFT_TISSUE	PIP4K2A →	+1.016	+1.484	.006	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	TPM3 →	+0.970	+0.972	<.001	.006	3	5
BREAST	CTSV →	-1.668	-1.027	<.001	<.001	3	5
LUNG_NSCLC_LUSC	SDCBP →	+1.217	+2.121	.006	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006930 vs ZNF594 — SOFT_TISSUE

Explore this scatter interactively →