Substrate-dependent cell migration

Across TCGA patient cohorts, RNA activity of the Substrate-dependent cell migration pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNX9, SSC5D, and C1R, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Substrate-dependent cell migration activity versus SNX9 in OV (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SNX9 →	+0.364	+0.052	<.001	<.001	3	10
CCRCC	SSC5D →	+0.953	+0.074	<.001	<.001	3	10
CCRCC	C1R →	+0.727	+0.063	<.001	<.001	3	10
CCRCC	C8B →	+0.706	+0.063	<.001	<.001	3	10
OV	AEBP1 →	+0.707	+0.061	<.001	<.001	3	10
UCEC	FLNA_S2152 →	+0.677	+0.073	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006929 vs SNX9 — OV

Explore this scatter interactively →