Substrate-dependent cell migration

Across TCGA patient cohorts, RNA activity of the Substrate-dependent cell migration pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRIM1, CRNKL1, and EZH2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Substrate-dependent cell migration activity versus PRIM1 in GBM (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRIM1 →	-0.640	-0.226	<.001	.001	3	6
OV	CRNKL1 →	-0.462	-0.180	.009	<.001	3	5
GBM	EZH2 →	-0.664	-0.157	<.001	.001	3	5
GBM	PCNA →	-0.596	-0.253	<.001	<.001	3	5
GBM	UBE2N →	-0.340	-0.244	<.001	.001	3	5
LSCC	SMIM26 →	-0.263	-0.117	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006929 vs PRIM1 — GBM

Explore this scatter interactively →