Substrate-dependent cell migration

Across TCGA cell cohorts, RNA activity of the Substrate-dependent cell migration pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRLF3, NEUROD4, and PLA1A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CRLF3 grouped by Substrate-dependent cell migration-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CRLF3 →	+0.203	+1.358	.003	<.001	3	3
OVARY	NEUROD4 →	-0.124	-1.006	.003	.005	3	3
OVARY	PLA1A →	-0.180	-1.841	.002	<.001	3	3
CNS	AQP12B →	-0.355	-1.428	<.001	.001	3	3
BLOOD_Leukemia	TFB2M →	+0.196	+1.339	.002	.005	3	3
KIDNEY	CRP →	-0.147	-0.367	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CRLF3 by Substrate-dependent cell migration activity — BLOOD_Leukemia

Explore this box plot interactively →