Substrate-dependent cell migration

Across TCGA cell cohorts, RNA activity of the Substrate-dependent cell migration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA2, ZFYVE9, and SMAD9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Substrate-dependent cell migration activity versus ITGA2 in LUNG_NSCLC_LUSC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ITGA2 →	+3.447	+0.361	.005	.004	3	5
LUNG_SCLC	ZFYVE9 →	-0.798	-1.175	.006	.002	3	4
URINARY_TRACT	SMAD9 →	-1.672	-1.856	<.001	<.001	3	4
STOMACH	MYEOV →	+4.098	+1.360	.008	.002	3	4
BONE	ZFX →	-0.754	-1.800	.008	.001	2	4
OESOPHAGUS	MAP3K12 →	-1.804	-0.944	.008	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006929 vs ITGA2 — LUNG_NSCLC_LUSC

Explore this scatter interactively →