Inflammatory cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Inflammatory cell apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SASH3, TNFAIP8L2, and CORO1A, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inflammatory cell apoptotic process activity versus SASH3 in GBM (Pearson r = 0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SASH3 →	+0.474	+0.055	<.001	.002	3	10
COAD	TNFAIP8L2 →	+0.548	+0.051	<.001	<.001	3	10
LSCC	CORO1A →	+0.590	+0.082	<.001	<.001	3	10
BRCA	CYBB →	+0.860	+0.051	<.001	<.001	3	10
CCRCC	CYRIB →	+0.300	+0.067	<.001	<.001	3	10
HNSC	DOCK10 →	+0.553	+0.103	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006925 vs SASH3 — GBM

Explore this scatter interactively →