Inflammatory cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Inflammatory cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFRSF13B, SRRD, and TRAV22, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inflammatory cell apoptotic process activity versus TNFRSF13B in BRCA (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TNFRSF13B →	+0.359	+0.238	<.001	.001	3	5
BRCA	SRRD →	-0.303	-0.209	.001	.004	3	5
BRCA	TRAV22 →	+0.611	+0.254	<.001	<.001	3	4
UCEC	SRPK2 →	-0.427	-0.492	.007	<.001	3	4
LUAD	MCAT →	-0.275	-0.345	.001	<.001	3	4
BRCA	PSMB8-AS1 →	+0.623	+0.283	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006925 vs TNFRSF13B — BRCA

Explore this scatter interactively →